Lab Publications

in press
Kim, K, Schedlbauer, A, Rollo, M, Karunakaran, S, Ekstrom AD, & Tandon, N. (in press). Network-based brain stimulation selectively impairs spatial retrieval. Brain Stimulation. doi:10.1016/j.brs.2017.09.016 pdf

Ekstrom, AD, Huffman, DJ, & Starrett, M. (in press). Interacting networks of brain regions underlie human spatial navigation: A review and novel synthesis of the literature. Journal of Neurophysiology. doi:10.1152/jn.00531.2017 manuscript

Kolarik, BS, Baer, T, Shahalaie, K, Yonelinas, AP, & Ekstrom, AD (in press). Close but no cigar: Spatial precision deficits following medial temporal lobe lesion s provide novel insight into theoretical models of navigation and memory. Hippocampus, 84-89. doi:10.1002/hipo.22801 pdf

Bouffard, N, Stokes, JD, Dramer, HJ, & Ekstrom, AD. (in press). Temporal encoding strategies result in boosts to final free recall comparable to spatial ones. Memory and Cognition. doi:10.3758/s13421-017-0742-z pdf

Ekstrom, AD, & Isham, EA. (in press). Human spatial navigation: representations across dimensions and scales. Current Opinion in Behavioral Science, 17, 84-89. doi:10.1016/j.cobeha.2017.06.005 pdf

Ekstrom, AD, & Ranganath, C. (in press). Space, time, and episodic memory: The hippocampus is all over the cognitive map. Hippocampus. doi:10.1002/hipo.22750 pdf

2017
Bohbot VD, Copara MS, Gotman J, & Ekstrom AD. (2017). Low-frequency theta oscillations in the human hippocampus during real-world and virtual navigation. Nature Communications, 8, 14415. DOI: 10.1038/ncomms14415. pdf

Lieberman JS, Kyle CT, Schedlbauer A, Stokes J, & Ekstrom AD. (2017). A Tale of Two Temporal Coding Strategies: Common and Dissociable Brain Regions Involved in Recency versus Associative Temporal Order Retrieval Strategies. Journal of Cognitive Neuroscience, 29(4), 739-754. DOI: 10.1162/jocn_a_01081. pdf

2016
Arnold AE, Iaria G, & Ekstrom AD. (2016). Mental simulation of routes during navigation involves adaptive temporal compression. Cognition, 157, 14-23. doi: 10.1016/j.cognition.2016.08.009 pdf

Kim K, Ekstrom AD, & Tandon N. (2016). A network approach for modulating memory processes via direct and indirect brain stimulation: Toward a causal approach for the neural basis of memory. Neurobiology of Learning and Memory, 134 Pt. A, 162-177. DOI: http://dx.doi.org/10.1016/j.nlm.2016.04.001 pdf

Kolarik BS, Shahlaie K, Hassan A, Borders AA, Kaufman KC, Gurkoff GE, Yonelinas AP, & Ekstrom AD. (2016). Impairments in precision, rather than spatial strategy, characterize performance on the virtual Morris water maze: a case study. Neuropsychologia, 80, 90-101. DOI: 10.1016/j.neuropsychologia.2015.11.013 pdf

Vass LK, Copara MS, Seyal M, Shahlaie K, Tomaszewski Farias S, Shen PY, & Ekstrom AD. (2016). Oscillations Go the Distance: Low-Frequency Human Hippocampal Oscillations Code Spatial Distance in the Absence of Sensory Cues during Teleportation. Neuron, 89(6), 1180-1186. DOI: 10.1016/j.neuron.2016.01.045 Article: pdf Supplement: pdf

2015
Ekstrom AD. Why vision is important to how we navigate. (2015). Hippocampus, 25(6), 731-735. DOI: 10.1002/hipo.22449 pdf

Kyle CT, Smuda DN, Hassan AS, & Ekstrom AD. (2015). Roles of human hippocampal subfields in retrieval of spatial and temporal context. Behavioral Brain Research, 278, 549-558. DOI: 10.1016/j.bbr.2014.10.034 pdf

Kyle CT, Stokes JD, Lieberman JS, Hassan AS, & Ekstrom AD. (2015). Successful retrieval of competing spatial environments in humans involves hippocampal pattern separation mechanisms. eLife, 4, e10499. pdf

Stokes J, Kyle C, & Ekstrom AD. (2015). Complementary roles of human hippocampal subfields in differentiation and integration of spatial context. Journal of Cognitive Neuroscience, 27(3), 546–559. doi: 10.1162/jocn_a_00736 pdf

Suthana NA, Parikshak NN, Ekstrom AD, Ison MJ, Knowlton BJ, Bookheimer SY, & Fried I. (2015). Specific responses of human hippocampal neurons are associated with bedtter memory. Proceedings of the National Academy of Sciences, 112(33), 10503-10508. DOI: 10.1073/pnas.1423036112 pdf

Watrous AJ, Fell J, Ekstrom AD, & Axmacher, N. (2014). More than spikes: common oscillatory mechanisms for content specific neural representations during perception and memory. Current Opinion in Neurobiology, 31C, 33–39. DOI: 10.1016/j.conb.2014.07.024 pdf

Yushkevich PA, Amaral RSC, Augustinack JC, Bender AR, Bernstein JD, … Ekstrom A, … Zeineh MM. (2015). Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol. Neuroimage, 111, 526-541. DOI: 10.1016/j.neuroimage.2015.01.004 pdf

2014
Copara MS, Hassan AS, Kyle CT, Libby LA, Ranganath C, & Ekstrom AD. (2014). Complementary roles of human hippocampal subregions during retrieval of spatiotemporal context. Journal of Neuroscience, 34(20), 6834–6842. DOI: 10.1523/JNEUROSCI.5341-13.2014 pdf

Ekstrom AD. (2014). Cognitive neuroscience: navigating human verbal memory. Current Biology, 24(4), R167–R168. DOI: 10.1016/j.cub.2013.12.043 pdf

Ekstrom AD, Arnold AEGF, & Iaria G. (2014). A critical review of the allocentric spatial representation and its neural underpinnings: toward a network-based perspective. Frontiers in Human Neuroscience, 8:803. DOI: 10.3389/fnhum.2014.00803 pdf

Ekstrom AD & Watrous AJ. (2014). Multifaceted roles for low-frequency oscillations in bottom-up and top-down processing during navigation and memory. Neuroimage 85(Pt 2), 667-677. DOI: 10.1016/j.neuroimage.2013.06.049 pdf

Schedlbauer AM, Copara MS, Watrous AJ, & Ekstrom AD. (2014). Multiple interacting brain areas underlie successful spatiotemporal memory retrieval in humans. Scientific Reports, 4, 6431. DOI: 10.1038/srep06431 pdf

Watrous AJ & Ekstrom AD. (2014). The spectro-contextual encoding and retrieval theory of episodic memory. Frontiers in Human Neuroscience, 8:75. DOI: 10.3389/fnhum.2014.00075 pdf

Zhang H, Zherdeva K, & Ekstrom AD. (2014). Different “routes” to a cognitive map: dissociable forms of spatial knowledge derived from route and cartographic map learning. Memory & Cognition, 42(7), 1106–1117. DOI: 10.3758/s13421-014-0418-x pdf

2013
Gruber MJ, Watrous AJ, Ekstrom AD, Ranganath C, & Otten LJ. (2013). Expected reward modulated encoding-related theta activity before an event. Neuroimage, 64, 68-74. DOI: 10.1016/j.neuroimage.2012.07.064 pdf

Lee DJ, Gurkoff GG, Izadi A, Berman RF, Ekstrom AD, Muizelaar P, Lyeth BG, & Shahlaie K. (2013). Medial septal nucleus theta frequency deep brain stimulation improves spatial working memory following traumatic brain injury. Journal of Neurotrauma, 30(2), 131-139. DOI: 10.1089/neu.2012.2646 pdf

Watrous AJ, Lee DJ, Izadi A, Gurkoff GG, Shahlaie K, & Ekstrom AD. (2013). A comparative study of human and rat hippocampal low frequency oscillations during spatial navigation. Hippocampus, 23(8), 656-661. DOI: 10.1002/hipo.22124 pdf

Watrous AJ, Tandon N, Connor CR, Pieters T, & Ekstrom AD.(2013). Frequency-specific increases in network connectivity underlie successful spatiotemporal memory retrieval. Nature Neuroscience, 16(3), 349-356. DOI: 10.1038/nn.3315 pdf

Zhang H & Ekstrom AD. (2013). Human Neural Systems Underlying Rigid and Flexible Forms of Allocentric Spatial Representation. Human Brain Mapping, 34(5), 1070-1087. DOI: 10.1002/hbm.21494 pdf

2012
Kern KC, Ekstrom AD, Suthana NA, Giesse BS, Montag M, Arshanapalli A, Bookheimer SY, & Sicotte NL. (2012). Fornix damage limits verbal memory functional compensation in multiple sclerosis. Neuroimage, 59(3), 2932-40. DOI: 10.1016/j.neuroimage.2011.09.071 pdf

Libby LA, Ekstrom AD, Ragland JD, & Ranganath C. (2012). Differential connectivity of perirhinal and parahippocampal cortices within human hippocampal subregions revealed by high-resolution functional imaging. Journal of Neuroscience, 32(19), 6550-6560. DOI: 10.1523/JNEUROSCI.3711-11.2012 pdf

Staba RJ, Ekstrom AD, Suthana NA, Burggren A, Fried I, Engel J Jr, & Bookheimer SY. (2012). Gray matter loss correlates with mesial temporal lobe neuronal hyper-excitability inside the human seizure-onset zone. Epilepsia, 53(1), 25-34. DOI: 10.1111/j.1528-1167.2011.03333.x pdf

Zhang H, Copara M, & Ekstrom AD. (2012). Differential Recruitment of Brain Networks Following Route and Cartographic Map Learning of Spatial Environments. PLoS ONE. 7(9), e44886. DOI: 10.1371/journal.pone.0044886 pdf

2011
Addante RJ, Watrous AJ, Yonelinas AP, Ekstrom AD, & Ranganath C. (2011). Prestimulus theta activity predicts correct source memory retrieval. Proceedings of the National Academy of Sciences, 108(26), 10702-10707. DOI: 10.1073/pnas.1014528108 pdf

Ekstrom AD, Copara MS, Isham EA, Wang W, & Yonelinas AP. (2011). Dissociable networks involved in spatial and temporal order source retrieval. Neuroimage, 56, 1803-1813. DOI: 10.1016/j.neuroimage.2011.02.033 pdf

Suthana N, Ekstrom AD, Moshirvaziri S, Knowlton B, & Bookheimer S. (2011). Dissociations within human hippocampal subregions during encoding and retrieval of spatial information. Hippocampus, 21(7), 694-701. DOI: 10.1002/hipo.20833 pdf

Watrous A, Fried I, & Ekstrom AD. (2011). Behavioral correlates of human hippocampal delta and theta oscillations during navigation. Journal of Neurophysiology, 105, 1747-1755. DOI: 10.1152/jn.00921.2010 pdf

2010
Donix M, Burggren AC, Suthana NA, Siddarth P, Ekstrom AD, Krupa AK, Jones M, Martin-Harris L, Ercoli LM, Miller KJ, Small GW, & Bookheimer SY. (2010). Family history of Alzheimer’s disease and hippocampal structure in healthy people. The American Journal of Psychiatry, 167(11), 1399-1406. DOI: 10.1176/appi.ajp.2010.09111575 pdf

Donix M, Burggren AC, Suthana NA, Siddarth P, Ekstrom AD, Krupa AK, Jones M, Rao A, Martin-Harris L, Ercoli LM, Miller KJ, Small GW, & Bookheimer SY. (2010). Longitudinal changes in medial temporal cortical thickness in normal subjects with the APOE-4 polymorphism. Neuroimage, 53(1), 37-43. DOI: 10.1016/j.neuroimage.2010.06.009 pdf

Ekstrom, AD. (2010). How and when the fMRI BOLD signal relates to underlying neural activity: The danger in dissociation. Brain Research Reviews, 62(2), 233-244. DOI: 10.1016/j.brainresrev.2009.12.004 pdf

Ekstrom AD. (2010). Navigation in Virtual Space: Psychological and Neural Aspects. In Encyclopedia of Behavioral Neuroscience (eds. Koob, Thompson and Le Moal). pdf

Jacobs J, Kahana MJ, Ekstrom AD, Mollison MV, & Fried I. (2010). A sense of direction in human entorhinal cortex. Proceedings of the National Academy of Sciences of the United States of America, 107(14), 6487-6492. DOI: 10.1073/pnas.0911213107 pdf

Jacobs J, Korolev IO, Caplan JB, Ekstrom AD, Litt B, Baltuch G, Fried I, Schulze-Bonhage A, Madsen JR, & Kahana MJ. (2010). Right-lateralized brain oscillations in human spatial navigation. Journal of Cognitive Neuroscience, 22(5), 824-836. DOI: 10.1162/jocn.2009.21240 pdf

Mukamel R, Ekstrom AD, Kaplan J, Iacoboni M, & Fried I. (2010). Single-neuron responses in humans during execution and observation of actions. Current Biology, 20(8), 750-756. DOI: 10.1016/j.cub.2010.02.045 pdf

Suthana NA, Krupa A, Donix M, Burggren A, Ekstrom AD, Jones M, Ercoli LM, Miller KJ, Siddarth P, Small GW, & Bookheimer SY. (2010). Reduced hippocampal CA2, CA3 and dentate gyrus activity in asymptotic people at genetic risk for Alzheimer’s disease. Neuroimage, 53(3), 1077-1084. DOI: 10.1016/j.neuroimage.2009.12.014 pdf

2009
Ekstrom AD, Bazih AJ, Suthana NA, Al-Hakim R, Ogura K, Zeineh M, Burggren AC, & Bookheimer SY. (2009). Advances in high-resolution imaging and computational unfolding of the human hippocampus. Neuroimage, 47(1), 42-49. DOI: 10.1016/j.neuroimage.2009.03.017 pdf

Ekstrom A, Suthana N, Millet D, Fried I, & Bookheimer S. (2009). Correlation between BOLD fMRI and theta-band local field potentials in the human hippocampal area. Journal of Neurophysiology, 101(5), 2668-2678. DOI: 10.1152/jn.91252.2008 pdf

Suthana NA, Ekstrom AD, Moshirvaziri S, Knowlton B, & Bookheimer SY. (2009). Human hippocampal CA1 involvement during allocentric encoding of spatial information. Journal of Neuroscience, 29(34), 10512-10519. DOI: 10.1523/JNEUROSCI.0621-09.2009 pdf

2008
Burggren AC, Zeineh MM, Ekstrom AD, Braskie MN, Thompson PM, Small GW, & Bookheimer SY. (2008). Reduced cortical thickness in hippocampal subregions among cognitively normal Apolipoprotein E e4 carriers. Neuroimage, 41(4), 1177-83. DOI: 10.1016/j.neuroimage.2008.03.039 pdf

Ekstrom A, Suthana N, Behnke E, Salamon N, Bookheimer S, & Fried I. (2008). High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy. Technical note. Journal of Neurosurgery, 108(4), 812-815. DOI: 10.3171/JNS/2008/108/4/0812 pdf

2007
Ekstrom AD and Bookheimer SY. (2007). Spatial and temporal episodic memory retrieval recruit dissociable functional networks in the human brain. Learning and Memory, 14(10), 645-654. DOI: 10.1101/lm.575107 pdf

Ekstrom A, Viskontas I, Kahana MJ, Jacobs J, Upchurch K, Bookheimer SY, & Fried I. (2007). Contrasting roles of neural firing rate and local field potentials in human memory. Hippocampus, 17(8), 606-617. DOI: 10.1002/hipo.20300 pdf

Jacobs J, Kahana MJ, Ekstrom AD, & Fried I. (2007). Brain oscillations control timing of single-neuron activity in humans. Journal of Neuroscience, 27(14), 3839–3844. DOI: 10.1523/JNEUROSCI.4636-06.2007 pdf

Viskontas I, Ekstrom AD, Wilson CL, & Fried I. (2007). Characterizing interneuron and pyramidal cells in the human medial temporal lobe in vivo using extracellular recordings. Hippocampus, 17(1), 49-57. DOI: 10.1002/hipo.20241 pdf

2005
Ekstrom AD, Caplan JB, Shattuck K, Fried I, & Kahana MJ. (2005). Human hippocampal theta activity during virtual navigation. Hippocampus, 15(7), 881-889. DOI: 10.1002/hipo.20109 pdf

2003
Ekstrom AD, Kahana MJ, Caplan JB, Fields TA, Isham EA, Newman E, & Fried I. (2003). Cellular networks underlying human spatial navigation. Nature, 425(6954), 184-188. DOI: 10.1038/nature01964 pdf

2001
Redish AD, Battaglia FP, Chawla MK, Ekstrom AD, Gerrard JL, Lipa P, Rosenzweig ES, Worley PF, Guzowski JF, McNaughton BL, & Barnes CA. (2001). Independence of firing correlates of anatomically proximate hippocampal pyramidal cells. Journal of Neuroscience, 21(5), 1-6. pdf

Ekstrom AD, Meltzer J, McNaughton BL, & Barnes CA. (2001). NMDA receptor antagonism blocks Experience-Dependent Expansion of Hippocampal Place Fields. Neuron, 31, 631-638. pdf